Current Trends in Simvastatin Therapy for Enhanced Efficiency

Statins are mainly used as the inhibitors of enzyme 3-hydroxy-3 methyl glutaryl coenzyme A (HMG COA) reductase which is responsible for the synthesis of cholesterol. Apart from the cholesterol reducing activity they also facilitate as antiinflammatory and cardio-protective agents. Solubility is one of the main parameter for any drug to achieve the expected therapeutic effects. Since Simvastatin is poorly soluble drug with less half life of about 2 hours, various types of formulations are being currently prepared to enhance its solubility which in turn may improve the bioavailability of the drug. Studies reveal that different methodologies were carried out to overcome the bioavailability issue which is the key limiting factor. The present study focuses on the different types of novel formulation approaches of Simvastatin, currently available for enhancing the bioavailability and efficacy of the drug in the biological system.